Coumarins and derivatives
Medchemexpress LLC 4-Methylesculetin | 529-84-0 | 1 ML
4-Methylesculetin is an orally active coumarin derivative known for its potent antioxidant and anti-inflammatory properties. It demonstrates inhibitory effects on myeloperoxidase activity and offers protection against bone resorption by decreasing elevated levels of bone-joint exoglycosidases, cathepsin-D, and tartrate resistant acid phosphatases. This compound also helps ameliorate upregulated non-enzymatic inflammatory markers such as TNF-α, IL-1β, IL-6, COX-2, and PGE2, making it a promising subject for inflammatory disease research.
- Orally active coumarin derivative
- Potent antioxidant and anti-inflammatory activities
- Inhibits myeloperoxidase activity
- Protects against bone resorption
- Ameliorates upregulated non-enzymatic inflammatory markers
- Promising for research on inflammatory diseases
Medchemexpress LLC Coumarin 480 | 41267-76-9 | MFCD00041844 | 100.0% | 255.31 g/mol | C16H17NO2 | 100 MG
Coumarin 480 (Coumarin 102) is a laser dye and fluorescent probe used in photophysics and spectroscopy applications. Supplied as a high-purity solid for research use, the compound is typically used in fluorescence studies, solvent relaxation dynamics, and as a laser dye in optical experiments. Store protected from light and follow supplier documentation for handling and stability.
- High purity: 99.95%.
- Molecular weight: 255.31 g/mol.
- Chemical formula: C16H17NO2.
- Available in small-mass quantities for laboratory use.
- Storage: keep at 4°C and protect from light.
- In solvent stability: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC 4-Ethoxycoumarin | 35817-27-7 | 99.93% | 190.20 | 5 G
4-Ethoxycoumarin is an antimicrobial compound used for research purposes. It has a molecular weight of 190.20 and a purity of 99.93%. The compound should be stored at room temperature for up to 3 years. When in solvent, it can be stored at -80°C for 2 years or -20°C for 1 year. For shipping, it can be transported at room temperature if the duration is less than 2 weeks. Keep the container tightly sealed in a cool, well-ventilated area, away from direct sunlight and sources of ignition.
- Antimicrobial properties
- High purity of 99.93%
- Stable for 3 years at room temperature
- Stable for 2 years at -80°C in solvent
- Stable for 1 year at -20°C in solvent
- Suitable for research use
Medchemexpress LLC 4-Hydroxycoumarin (Standard) | 1076-38-6 | 100 MG
4-Hydroxycoumarin (Standard) is the analytical standard of 4-Hydroxycoumarin, intended for research and analytical applications. It is an orally active coumarin derivative and a versatile heterocyclic scaffold used in the synthesis of various organic compounds.
- Possesses both electrophilic and nucleophilic properties.
- Functions as an HIV protease inhibitor and tyrosine kinase inhibitor.
- Exhibits anti-inflammatory effects.
- Shows antibacterial effects.
- Demonstrates anti-tumor effects.
Medchemexpress LLC 4-Hydroxycoumarin | 1076-38-6 | 1000 G
4-Hydroxycoumarin is an orally active coumarin derivative, a versatile heterocyclic scaffold used in the synthesis of various organic compounds. It exhibits both electrophilic and nucleophilic properties. It acts as an HIV protease inhibitor and tyrosine kinase inhibitor, and also possesses anti-inflammatory, antibacterial, and anti-tumor effects.
- Orally active coumarin derivative
- Versatile scaffold for organic synthesis
- Exhibits electrophilic and nucleophilic properties
- Acts as an HIV protease and tyrosine kinase inhibitor
- Possesses anti-inflammatory, antibacterial, and anti-tumor effects
- High purity white to off-white solid
- Shown to inhibit tumor growth in mouse melanoma models
- Reduces colitis symptoms in rat models
Medchemexpress LLC 7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester | 134471-24-2 | MFCD00037568 | ≥95.0% | 25 MG
7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester is the amine-reactive succinimidyl ester of 7-Hydroxycoumarin-3-carboxylic acid. It is a blue fluorescent dye used for labeling proteins and nucleic acids.
- Amine-reactive succinimidyl ester
- Blue fluorescent dye
- Used for labeling proteins
- Used for labeling nucleic acids
Cayman Chemical 7-Acetoxy-4-methylcoumarIn 10g
A fluorogenic substrate for carboxylesterase and AChE; upon hydrolysis by carboxylic esterase or AChE, 4-MU is released, which displays pH-dependent excitation maxima of 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively, and an emission maximum between 445-454 nm; has been used to detect the presence of carboxylesterases in isolated human lung tissue
Medchemexpress LLC 7-Hydroxycoumarin-4-acetic acid | 6950-82-9 | 10 G
7-Hydroxycoumarin-4-acetic acid is a pH-indicator dye. It is covalently bound to bovine serum albumin (BSA) at the positions of reactive amino groups (λmax=326 nm).
- Functions as a pH-indicator dye
- Covalently binds to bovine serum albumin (BSA) at reactive amino groups (λmax=326 nm)
- Shows cytotoxicity against mouse B16-F10 cells
- Shows cytotoxicity against human HT-29 cells
- Shows cytotoxicity against human HepG2 cells
Medchemexpress LLC Coumarin boronic aci 10mg
Coumarin boronic acid is a fluorescent probe The excitation and emission wavelengths of coumarin boronic acid are set to 360 nm and 430 nm respectively Coumarin boronic acid can be used to monitor the formation of amino acid and protein hydroxyl peroxides in real time which is beneficial for understanding the mechanisms of oxidative stress and protein post-translational modification[1]
Medchemexpress LLC 7-methoxycoumarin-3-carboxylic acid N-succinimidyl ester | 150321-92-9 | MFCD00467593 | ≥97.0% | 10 MG
7-Methoxycoumarin-3-carboxylic acid, succinimidyl ester is a coumarin-derived, amine-reactive fluorescent labeling reagent used to conjugate peptides and proteins for blue/UV fluorescence detection and intracellular imaging applications. The NHS ester enables efficient coupling to primary amines under mild conditions.
- Amine-reactive N-hydroxysuccinimide (NHS) ester for efficient conjugation.
- Strong blue fluorescence suitable for labeling peptides and proteins.
- Useful for synthesis of hydrophilic dye probes and intracellular viscosity measurements.
- Available in small research pack sizes for mg-scale conjugation experiments.
- Typical purity ≥97% (HPLC); consult the certificate of analysis for batch-specific data.
Medchemexpress LLC 7-methoxycoumarin-3-carboxylic acid | 20300-59-8 | MFCD00452770 | ≥97.0% | 220.18 | C11H8O5 | 1 G
7-Methoxycoumarin-3-carboxylic acid is a coumarin-derived fluorescent dye used to label peptides and other biomolecules for biochemical assays and HPLC derivatization. It is supplied as a solid with high purity and is prepared as a DMSO stock for use in fluorescence-based assays; handle and store protected from light.
- Excitation and emission in the near-UV/blue range (Ex ≈345-355 nm, Em ≈405-450 nm).
- Suitable for peptide labeling and HPLC derivatization.
- High purity appropriate for analytical applications (~97.0%).
- Soluble in DMSO (≈8 mg/mL with sonication and warming).
- Store protected from light; in solution, keep frozen for extended stability.
Medchemexpress LLC Coumarin 106 | 41175-45-5 | MFCD00041949 | 6498.0% | 281.35 g/mol | C18H19NO2 | 10 MG
Coumarin 106 is a dipolar laser dye with fluorescent properties that also displays cholinesterase inhibitory activity. Supplied as a research-grade solid, it is used in fluorescence studies, dye-laser applications, and biochemical assays where cholinesterase modulation or fluorescent probes are required.
- Dipolar laser dye with fluorescent properties.
- Demonstrates AChE and BChE inhibition for biochemical studies.
- Molecular formula C18H19NO2; molecular weight 281.35 g/mol.
- Available in small research pack sizes suitable for analytical use.
- Supplied as a solid for standard laboratory storage and handling.
Medchemexpress LLC Coumarin-C2-TCO | 2488174-16-7 | >98.0% | 455.55 | C25H33N3O5 | 10 MG
Coumarin-C2-TCO is a coumarin-derived fluorescent dye functionalized with a trans-cyclooctene (TCO) reactive handle that undergoes rapid inverse electron-demand Diels-Alder (iEDDA) reactions with tetrazine-bearing molecules for bioorthogonal labeling and conjugation.
- Fluorescent coumarin core provides a dye scaffold for imaging and detection.
- TCO reactive handle enables fast, bioorthogonal iEDDA conjugation to tetrazines.
- Suitable for labeling biomolecules and developing fluorescent probes in chemical biology workflows.
- Offered in small research quantities for synthesis and assay development.